BP211PSemester 21 creditsPractical
Physical Pharmaceutics (Practical)
Complete unit-wise syllabus for BP211P as per the PCI B.Pharm NEP 2020 curriculum (Semester 2 — Organic Chemistry + Biostatistics).
URL:
https://pharmacode.vercel.app/syllabus/semester-2/bp211p-physical-pharmaceutics-practical/Course Objectives
- Introduce basic laboratory techniques for determining physicochemical properties such as surface tension, viscosity, and density in pharmaceutical systems.
- Develop understanding of interfacial phenomena and surfactant behavior, including micelles, critical micellar concentration (CMC), and HLB in formulation design.
- Train students in evaluating disperse systems through sedimentation studies and the effect of suspending agents.
- Provide practical experience in powder characterization, including particle size distribution, density, flow properties, porosity, and the role of glidants.
- Develop skills in determining solubility, partition coefficient, buffer capacity, and related equilibria relevant to drug formulation.
Unit-wise Syllabus
1 Units1
Laboratory Practicals & Experiments (45 Hours)45 Hours- 1. Determination of surface tension of given liquids by drop count method and drop weight method.
- 2. Determination of critical micellar concentration (CMC) of surfactants.
- 3. Determination of viscosity of liquids using Ostwald’s viscometer and Brookfield viscometer.
- 4. Determination of HLB value of a surfactant.
- 5. Calculation of isotonicity by different methods (Sodium Chloride Equivalent Method).
- 6. Determination of particle size and particle size distribution using sieving method.
- 7. Determination of particle size and particle size distribution using microscopic method.
- 8. Determination of densities and derived properties of powders (bulk density, tapped density, Hausner ratio, Carr’s compressibility index), true density, and porosity.
- 9. Determination of angle of repose and influence of glidants on angle of repose.
- 10. Determination of solubility of a drug at different pH/buffer systems at room temperature.
- 11. Determination of partition coefficient of a drug in n-octanol and water system.
- 12. Determination of partition coefficient of a drug in benzene and water system.
- 13. Determination of critical solution temperature and composition of phenol–water system.
- 14. Determination of specific surface area of charcoal by adsorption of acetic acid on activated charcoal.
- 15. Determination of buffer capacity at various stages of titration of a weak acid against a strong base and determination of pKa. Note: Compare the values of various physicochemical properties with marketed formulations wherever possible.
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Recommended Textbooks & References
- Sinko, P. J. Martin’s Physical Pharmacy and Pharmaceutical Sciences. Lippincott Williams & Wilkins.
- Aulton, M. E. and Taylor, K. M. G. Aulton’s Pharmaceutics: The Design and Manufacture of Medicines. Elsevier.
- Lachman, L., Lieberman, H. A. and Kanig, J. L. The Theory and Practice of Industrial Pharmacy. CBS Publishers & Distributors.
- Allen, L. V., Popovich, N. G. and Ansel, H. C. Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems. Lippincott Williams & Wilkins.
- Cooper, S. J. and Gunn, C. Cooper and Gunn’s Tutorial Pharmacy. CBS Publishers & Distributors.
What's coming next on this page
- Previous year question papers (PYQ)
- Topic-wise short notes and revision summaries
- MCQs and self-assessment quizzes
- Suggested external resources and video tutorials
Other subjects in Semester 2
BP201TApplied Biostatistics and Data Analytics for Pharmaceutical SciencesBP202TBiochemistryBP203THuman Anatomy, Physiology and Pathophysiology IIBP204TPharmaceutical Organic ChemistryBP205TPharmacognosy and PhytochemistryBP206TPhysical PharmaceuticsBP207PBiochemistry (Practical)BP208PHuman Anatomy, Physiology and Pathophysiology II (Practical)BP209PPharmaceutical Organic Chemistry (Practical)BP210PPharmacognosy and Phytochemistry (Practical)BP212P SECSEC Elective — Communication Skills / Mental Well-Being / Basic Computer Operations (Practical)