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BP204TSemester 24 creditsTheory

Pharmaceutical Organic Chemistry

Complete unit-wise syllabus for BP204T as per the PCI B.Pharm NEP 2020 curriculum (Semester 2 — Organic Chemistry + Biostatistics).

All Sem 2 Subjects
URL:https://pharmacode.vercel.app/syllabus/semester-2/bp204t-pharmaceutical-organic-chemistry/

Unit-wise Syllabus

5 Units
1
Fundamentals of Organic Chemistry10 Hours
  • Bonding in organic molecules: sp3, sp2, sp hybridisation; orbital overlap and resonance
  • Electronic effects: inductive effect, resonance/mesomeric effect, hyperconjugation, and their influence on acidity/basicity and reactivity
  • Stereochemistry: chirality, enantiomers, diastereomers, R/S configuration; optical activity; racemic mixtures; separation methods
2
Aliphatic Hydrocarbons8 Hours
  • Alkanes: nomenclature, physical properties, conformational analysis (ethane, butane), free radical halogenation
  • Alkenes: nomenclature, geometric isomerism (E/Z), electrophilic addition reactions (HX, H2O, halogenation), Markovnikov's rule, ozonolysis
  • Alkynes: nomenclature, acidity of terminal alkynes, reactions — hydration, reduction
3
Aromatic Compounds8 Hours
  • Benzene: structure, Hückel's aromaticity rule; resonance energy; electrophilic aromatic substitution (EAS) — nitration, sulfonation, halogenation, Friedel-Crafts
  • Directing effects of substituents (ortho/para vs. meta directors); mechanism of EAS
  • Phenols, aryl halides, aromatic amines — properties and reactions; pharmaceutical applications
4
Functional Group Chemistry8 Hours
  • Alcohols and ethers: nomenclature, physical properties, reactions (oxidation, dehydration, esterification, Lucas test, ether formation)
  • Aldehydes and ketones: nomenclature; nucleophilic addition reactions; oxidation/reduction; aldol condensation; pharmaceutical applications
  • Carboxylic acids and derivatives: acidity; ester, amide, anhydride formation; nucleophilic acyl substitution reactions
5
Amines, Amides and Stereoisomerism9 Hours
  • Amines: classification, nomenclature, basicity; reactions — acylation, alkylation, diazotization; pharmaceutical amines
  • Amides: formation, hydrolysis; lactams (β-lactam antibiotics); significance in drug structures
  • Optical isomerism: chiral centres, Fischer projections, Cahn-Ingold-Prelog rules; geometric and conformational isomerism in drug molecules

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