BP510PSemester 52 creditsPractical
Systemic Pharmacology II (Practical)
Complete unit-wise syllabus for BP510P as per the PCI B.Pharm NEP 2020 curriculum (Semester 5 — QA + Innovation + Drug Delivery).
URL:
https://pharmacode.vercel.app/syllabus/semester-5/bp510p-systemic-pharmacology-ii-practical/Course Objectives
- Provide understanding of the theoretical and practical aspects of different pharmacological experiments using virtual simulations and video demonstrations.
- Develop skills to assess drug effects on various systems such as cardiovascular, respiratory, skeletal muscle, and gastrointestinal using simulation models.
- Familiarize the learners with experimental methodologies such as Langendorff’s heart preparation, spasmogenic and spasmolytic effects, and PA2 value determination using Schild plot.
- Provide knowledge of the modern techniques for drug evaluation, such as intraocular pressure measurement, nitric oxide estimation, neutrophil function tests and spirometry.
- Explore clinical pharmacology aspects through case studies on drug interactions, management of cardiovascular and respiratory diseases, and plasma volume expanders.
Unit-wise Syllabus
1 Units1
Laboratory Practicals & Experiments (60 Hours)60 Hours- 1. Evaluation of analgesic activity of centrally and peripherally acting analgesics using Eddie's hot plate, tail-flick, tail immersion, and acetic acid-induced writhing methods through interactive computer simulation.
- 2. Evaluation of antiepileptic activity using maximal electroconvulsive shock (MES)- induced seizures through interactive computer simulation.
- 3. Demonstration of the antiepileptic activity using pentylenetetrazol-induced seizures through interactive computer simulation.
- 4. Evaluation of antidepressant activity of drugs using the tail suspension test through interactive computer simulation.
- 5. Demonstration and study of locomotor activity using actophotometer through interactive computer simulation.
- 6. Evaluation of antianxiety activity using the elevated plus maze or zero maze model through interactive computer simulation.
- 7. Evaluation of antipsychotic activity of drugs using inhibition of conditioned response on Cook's pole climbing apparatus through interactive computer simulation.
- 8. Study of the effect of drugs on learning and memory using the Morris water maze test through interactive computer simulation.
- 9. Study of antiulcer activity using indomethacin-induced or pylorus ligation-induced ulcer models.
- 10. Estimation of the concentration of oxytocin on isolated rat uterus preparation using a suitable method through interactive computer-based simulation.
- 11. Estimation of drug concentration by 3-point or 4-point bioassay through interactive computer simulation.
- 12. Bioassay of histamine using matching, bracketing, or interpolation methods on suitable isolated tissue preparation with the help of interactive computer simulation.
- 13. Study of cell culture techniques, including types of cell culture, laboratory instruments/equipment, culture media, and growth of cell cultures in laboratory facilities.
- 14. Study of antibacterial sensitivity testing of urine culture using techniques such as the disc diffusion method (theoretical details/case studies).
- 15. Demonstration using databases and software packages for predicting drug activity, ADME properties, and toxicity.
- 16. Study of electrophoresis of protein and DNA samples and gel visualization techniques.
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Recommended Textbooks & References
- Ghosh, M. N. Fundamentals of Experimental Pharmacology. Hilton & Company.
- Vogel, H. G. Drug Discovery and Evaluation: Pharmacological Assays. Springer.
- Hofmann, F. B. Handbook of Experimental Pharmacology (HEP Series). Springer Nature.
What's coming next on this page
- Previous year question papers (PYQ)
- Topic-wise short notes and revision summaries
- MCQs and self-assessment quizzes
- Suggested external resources and video tutorials
Other subjects in Semester 5
BP501TBiomedicinal ChemistryBP502TIndustrial PharmacognosyBP503TInnovation and Startup EcosystemBP504TPharmaceutical Dosage Form IIBP505TPharmaceutical Quality AssuranceBP506TSystemic Pharmacology IIBP507PBiomedicinal Chemistry (Practical)BP508PIndustrial Pharmacognosy (Practical)BP509PPharmaceutical Dosage Form II (Practical)