BP501TSemester 53 creditsTheory
Biomedicinal Chemistry
Complete unit-wise syllabus for BP501T as per the PCI B.Pharm NEP 2020 curriculum (Semester 5 — QA + Innovation + Drug Delivery).
URL:
https://pharmacode.vercel.app/syllabus/semester-5/bp501t-biomedicinal-chemistry/Unit-wise Syllabus
5 Units1
Drug Design Strategies9 Hours- Rational drug design: target identification and validation; lead discovery (HTS, natural products, virtual screening); lead optimisation
- Combinatorial chemistry: solid-phase synthesis, split-pool synthesis; virtual combinatorial libraries; ADMET prediction in silico
- Fragment-based drug discovery: fragment libraries, SPR, NMR screening; growing and linking strategies
2
QSAR — Quantitative Structure-Activity Relationships9 Hours- Hansch analysis: physicochemical parameters (π, σ, Es), correlation equations; applications in drug design
- Free-Wilson method: structural parameters; comparison with Hansch; limitations
- 3D-QSAR: CoMFA (Comparative Molecular Field Analysis), CoMSIA; pharmacophore modelling; database screening
3
Antiviral and Anticancer Agents9 Hours- Antiviral drugs: nucleoside/nucleotide analogues (acyclovir, tenofovir, lamivudine) — mechanism, SAR; HIV protease inhibitors, NNRTI; neuraminidase inhibitors (oseltamivir, zanamivir)
- Anticancer drugs: alkylating agents (cyclophosphamide, cisplatin), antimetabolites (methotrexate, 5-FU, cytarabine), natural products (vinca alkaloids, taxanes, anthracyclines), targeted therapy (imatinib, erlotinib, trastuzumab)
4
Antidiabetic and Antilipidemic Agents9 Hours- Antidiabetic drugs: insulin analogues (structural modifications); biguanides (metformin — mechanism); sulfonylureas (glibenclamide — SAR); TZDs (pioglitazone — PPARγ agonism); DPP-4 inhibitors (sitagliptin — SAR); SGLT2 inhibitors (dapagliflozin)
- Antilipidemic drugs: statins (atorvastatin, rosuvastatin — HMG-CoA reductase inhibition, SAR); fibrates (fenofibrate — PPARα); ezetimibe; PCSK9 inhibitors
5
Prodrug Concept and Bioisosterism9 Hours- Prodrug concept: definition, types (carrier-linked, bipartite, tripartite; bioprecursor prodrugs); examples: enalapril, levodopa, valacyclovir, codeine
- Soft drugs: definition, concept; examples in ophthalmic and dermatological agents
- Bioisosterism: classical and non-classical bioisosteres; application in improving ADMET properties; examples: NH→O, COOH→tetrazole, F substitution
Get complete notes for BP501T
Click any unit above to download its PDF notes — free, no login required
What's coming next on this page
- Reference textbooks and recommended reading list
- Previous year question papers (PYQ)
- Topic-wise short notes and revision summaries
- Suggested external resources and video tutorials
Other subjects in Semester 5
BP502TIndustrial PharmacognosyBP503TInnovation and Startup EcosystemBP504TPharmaceutical Dosage Form IIBP505TPharmaceutical Quality AssuranceBP506TSystemic Pharmacology IIBP507PBiomedicinal Chemistry (Practical)BP508PIndustrial Pharmacognosy (Practical)BP509PPharmaceutical Dosage Form II (Practical)BP510PSystemic Pharmacology II (Practical)