BP507PSemester 52 creditsPractical
Biomedicinal Chemistry (Practical)
Complete unit-wise syllabus for BP507P as per the PCI B.Pharm NEP 2020 curriculum (Semester 5 — QA + Innovation + Drug Delivery).
URL:
https://pharmacode.vercel.app/syllabus/semester-5/bp507p-biomedicinal-chemistry-practical/Course Objectives
- Comprehend the fundamental principles of drug synthesis and apply them to the preparation of selected drug molecules and intermediates.
- Develop practical skills in performing laboratory techniques for the synthesis of organic compounds, including the use of microwave irradiation.
- Understand and apply the principles of drug assay to quantitatively analyze the purity and concentration of given drug samples.
- Learn and utilize computational tools to predict physicochemical and ADME properties of drug molecules.
- Apply molecular docking techniques to predict drug-target interactions.
Unit-wise Syllabus
1 Units1
Laboratory Practicals & Experiments (60 Hours)60 Hours- 1. Preparation of Drugs / Intermediates (Any 4); • 7-Hydroxy-4-methyl coumarin; • Thiobarbituric acid; • 2,3-Diphenylquinoxaline; • Sulphanilamide; • Triphenyl imidazole; • Perform synthesis of intermediate/drug using microwave irradiation or green chemistry techniques.
- 2. Assay of Drugs (Any 4); • Sulpha drugs; • Metronidazole; • Isoniazid; • Phenobarbitone; • Benzyl penicillin; • Chloroquine
- 3. Drug Design & Computational Tools (Any 4); • Calculate physicochemical and ADME properties using Swiss ADME (e.g. logP, molecular weight, H-bond donors/acceptors); • Perform basic molecular docking studies using any of open-source academic tools.
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Recommended Textbooks & References
- 1. Abraham, D. J. and Griffin, J. L. Burger’s Medicinal Chemistry and Drug Discovery. Wiley.
- Finar, I. L. Organic Chemistry. Pearson Education.
- Furniss, B. S., Hannaford, A. J., Smith, P. W. G. and Tatchell, A. R. Vogel’s Textbook of Practical Organic Chemistry. Pearson Education.
- Lednicer, D. The Organic Chemistry of Drug Synthesis. Wiley.
- Patrick, G. L. An Introduction to Medicinal Chemistry. Oxford University Press.
- Remington. The Science and Practice of Pharmacy. Pharmaceutical Press.
- Williams, D. A., Lemke, T. L. and Roche, V. F. Foye’s Principles of Medicinal Chemistry. Lippincott Williams & Wilkins.
- Wilson, C. O., Beale, J. M. and Block, J. H. Wilson and Gisvold’s Textbook of Organic Medicinal and Pharmaceutical Chemistry. Lippincott Williams & Wilkins.
- Indian Pharmacopoeia. Indian Pharmacopoeia Commission.
- Brown, N. Artificial Intelligence in Drug Discovery. Cambridge: Royal Society of Chemistry.
What's coming next on this page
- Previous year question papers (PYQ)
- Topic-wise short notes and revision summaries
- MCQs and self-assessment quizzes
- Suggested external resources and video tutorials
Other subjects in Semester 5
BP501TBiomedicinal ChemistryBP502TIndustrial PharmacognosyBP503TInnovation and Startup EcosystemBP504TPharmaceutical Dosage Form IIBP505TPharmaceutical Quality AssuranceBP506TSystemic Pharmacology IIBP508PIndustrial Pharmacognosy (Practical)BP509PPharmaceutical Dosage Form II (Practical)BP510PSystemic Pharmacology II (Practical)