BP410PSemester 41 creditsPractical
Systemic Pharmacology I (Practical)
Complete unit-wise syllabus for BP410P as per the PCI B.Pharm NEP 2020 curriculum (Semester 4 — Medicinal Chemistry + 1st Internship).
URL:
https://pharmacode.vercel.app/syllabus/semester-4/bp410p-systemic-pharmacology-i-practical/Course Objectives
- Provide understanding of the theoretical and practical aspects of different pharmacological experiments using virtual simulations and video demonstrations.
- Develop skills to assess drug effects on various systems such as cardiovascular, respiratory, skeletal muscle, and gastrointestinal tract using simulation models.
- Familiarize the learners with experimental methodologies such as Langendorff’s heart preparation, spasmogen and spasmolytic effects, and PA2 value determination using Schild plot.
- Provide knowledge of modern techniques for drug evaluation.
- Explore clinical pharmacology aspects through case studies on drug interactions, management of cardiovascular and respiratory diseases, and plasma volume expanders.
Unit-wise Syllabus
1 Units1
Laboratory Practicals & Experiments (45 Hours)45 Hours- 1. To demonstrate Langendorff’s heart assembly and its applications in pharmacology (only video demonstration/or charts and illustrations).
- 2. Recording of the effects of different electrolytes, agonists and antagonists on the isolated and perfused frog heart preparation using interactive computer simulation experiment.
- 3. To study the effect of various drugs on blood pressure and heart rate anaesthetized dog using interactive computer simulation experiment.
- 4. Demonstration of the estimation of intraocular pressure on rabbit eye and human eye by using conventional Schiotz tonometer and non-contact tonometer.
- 5. To evaluate the muscle relaxant activity of drugs on Rota-rod apparatus using interactive computer simulation experiment.
- 6. Demonstration of the effect of spasmogens and spasmolytic using rabbit jejunum using interactive computer simulation experiment.
- 7. Determination of PA2 value of Atropine using a suitable isolated tissue preparation by Schild plot method with the help of hypothetical data using interactive computer simulation experiment.
- 8. Determination of PA2 value of Prazosin using a suitable isolated tissue preparation by Schild plot method with the help of hypothetical data using interactive computer simulation experiment.
- 9. To study the antiallergic effects of drugs using mast cell degranulation assay using interactive computer simulated experiment.
- 10. Evaluation of diuretic activity of drugs in rats using metabolic cages (simulation) and estimation of electrolytes in the urine samples/serum using flame photometer/commercially available kits.
- 11. Evaluation of effects of antihistaminic drugs on the histamine-induced bronchospasm in guinea pigs using interactive simulated experiment.
- 12. To study and analyse drug-drug interaction/ rational drug management of asthma with the help of Case Study/ hypothetical data/ any clinical report.
- 13. To study clinical pharmacology of the plasma volume expanders and their importance (using charts/open sources videos).
- 14. Demonstration of evaluation of anti-inflammatory activity in paw oedema model using plethysmometer using simulations.
- 15. Concept of Biobanking and its significance in drug screening.
- 16. Isolation of Polymorphonuclear cells from blood and evaluation of endotoxin-induced oxidative stress in them using Nitrobluetetrazolium dye method by colourimetry.
- 17. Determination of viability of cells (using isolated polymorphonuclear cells) by Trypan blue dye exclusion assay to determine cell viability using microscopy method.
- 18. Determination of anti-inflammatory activity of durgs in vitro using RBC membrane stabilization assay
- 19. Determination of protein concentrations using Bradford reagent and plotting of standard curve of bovine serum albumin.
- 20. Estimation of anticholinesterase inhibitory activity of drugs using Ellman’s reagent (DTNB)
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Recommended Textbooks & References
- 1. Ghosh, M. N. Fundamentals of Experimental Pharmacology. Hilton & Company.
- Hofmann, F. B. Handbook of Experimental Pharmacology (HEP Series). Springer Nature.
- Computer Assisted Learning (CAL) software packages for experimental pharmacology simulations.
What's coming next on this page
- Previous year question papers (PYQ)
- Topic-wise short notes and revision summaries
- MCQs and self-assessment quizzes
- Suggested external resources and video tutorials
Other subjects in Semester 4
BP401THerbal Drug TechnologyBP402TMedicinal ChemistryBP403TPharmaceutical BiotechnologyBP404TSocial Pharmacy and Public HealthBP405TSystemic Pharmacology IBP406PHerbal Drug Technology (Practical)BP407PMedicinal Chemistry (Practical)BP408PPharmaceutical Biotechnology (Practical)BP409PSocial Pharmacy and Public Health (Practical)BP411IInternship I (Mandatory)