BP402TSemester 43 creditsTheory
Medicinal Chemistry
Complete unit-wise syllabus for BP402T as per the PCI B.Pharm NEP 2020 curriculum (Semester 4 — Medicinal Chemistry + 1st Internship).
URL:
https://pharmacode.vercel.app/syllabus/semester-4/bp402t-medicinal-chemistry/Unit-wise Syllabus
5 Units1
Drug-Receptor Interactions and SAR Fundamentals9 Hours- Drug-receptor interactions: forces involved (covalent, ionic, hydrogen bonds, van der Waals, hydrophobic interactions); pharmacophore concept
- Structure-Activity Relationship (SAR): electronic effects, steric effects, lipophilicity; bioisosterism; prodrug design; soft drugs
- Drug metabolism and bioavailability: metabolic soft spots; prodrug strategies to improve bioavailability; ADMET properties in drug design
2
Analgesics, NSAIDs, and Cardiovascular Drugs9 Hours- Analgesics: opioid analgesics — morphine, codeine, pethidine, methadone — structural features, SAR, mechanism
- NSAIDs: salicylates (aspirin, diflunisal), para-aminophenol derivatives (paracetamol), pyrazolone derivatives, propionic acid derivatives (ibuprofen, naproxen), oxicam derivatives (piroxicam), COX-2 inhibitors (celecoxib) — SAR
- Cardiovascular drugs: antihypertensives (ACE inhibitors, ARBs, calcium channel blockers, beta-blockers), antiarrhythmics, antithrombotics — structural features and SAR
3
Antibacterial and Antifungal Agents9 Hours- Sulfonamides: structure, SAR, mechanism; trimethoprim; cotrimoxazole
- Fluoroquinolones: nalidixic acid, norfloxacin, ciprofloxacin, levofloxacin — SAR, mechanism of action
- Beta-lactam antibiotics: penicillins — structure, SAR, mechanism, resistance; cephalosporins — generations and SAR; aminoglycosides, tetracyclines, macrolides
- Antifungal agents: azoles (fluconazole, itraconazole) — mechanism and SAR; amphotericin B structure; echinocandins
4
CNS Drugs — Sedatives, Hypnotics and Antipsychotics9 Hours- Sedative-hypnotics: benzodiazepines — diazepam, lorazepam, alprazolam; SAR; mechanism at GABA-A receptor; non-benzodiazepines (zolpidem)
- Barbiturates: structure, SAR, mechanism; classification by duration; clinical applications and limitations
- Antipsychotics: phenothiazines (chlorpromazine, trifluoperazine) — SAR, dopamine receptor blockade; butyrophenones (haloperidol); atypical antipsychotics (clozapine, risperidone)
5
Antidepressants, Antiepileptics and Antivirals9 Hours- Antidepressants: TCAs (imipramine, amitriptyline) — SAR; SSRIs (fluoxetine, sertraline) — SAR; MAOIs — mechanism and examples
- Antiepileptics: hydantoins (phenytoin), barbiturates (phenobarbitone), succinimides (ethosuximide), valproic acid, carbamazepine, benzodiazepines — SAR and mechanism
- Antivirals: nucleoside analogues (acyclovir, zidovudine, lamivudine) — mechanism and SAR; protease inhibitors; neuraminidase inhibitors (oseltamivir); HIV drug classes and combination therapy
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What's coming next on this page
- Reference textbooks and recommended reading list
- Previous year question papers (PYQ)
- Topic-wise short notes and revision summaries
- Suggested external resources and video tutorials
Other subjects in Semester 4
BP401THerbal Drug TechnologyBP403TPharmaceutical BiotechnologyBP404TSocial Pharmacy and Public HealthBP405TSystemic Pharmacology IBP406PHerbal Drug Technology (Practical)BP407PMedicinal Chemistry (Practical)BP408PPharmaceutical Biotechnology (Practical)BP409PSocial Pharmacy and Public Health (Practical)BP410PSystemic Pharmacology I (Practical)BP411IInternship I (Mandatory)