BP309PSemester 32 creditsPractical
General Pharmacology (Practical)
Complete unit-wise syllabus for BP309P as per the PCI B.Pharm NEP 2020 curriculum (Semester 3 — Machine Learning + Pharmacology).
URL:
https://pharmacode.vercel.app/syllabus/semester-3/bp309p-general-pharmacology-practical/Course Objectives
- Understand the historical and foundational aspects of experimental pharmacology
- Develop knowledge and practical awareness of ethical and regulatory standards in laboratory animal care and use, as outlined in CCSEA guidelines
- Acquire skills in pharmacological data acquisition and analysis
- Interpret and construct dose-response curves (DRCs) and calculate and interpret pharmacological indices such as LD50, threshold and ceiling dose, slope of DRC, and PD₂,
- Calculate the pharmacokinetic parameters and analyse the roles of pharmacokinetic parameters in the drug effects, and dosing schedule.
Unit-wise Syllabus
1 Units1
Laboratory Practicals & Experiments (60 Hours)60 Hours- 1. To describe the contributions of renowned pharmacologists and their discoveries based on pharmacological experiments (Any 5 Noble Laureates whose research contributed to the development of Pharmacology).
- 2. To study various laboratory safety precautions, hazards, personal hygiene, commonly used tools, devices and instruments in experimental pharmacology.
- 3. To study common experimental animals including transgenic animals along with their applications in the pharmacological experiments in current drug discovery paradigm.
- 4. To study concept of 6Rs along with the maintenance and experimentation on laboratory animals as per the CCSEA guidelines.
- 5. To demonstrate collection/isolation of DNA and RNA using computer simulations and audiovisual aids.
- 6. To study important anaesthetics and euthanasia procedures for experimental animals.
- 7. To demonstrate different routes drug administration using computer simulation and understand the significance of each route along with the maximum administrable dose.
- 8. To study preparation of different types of physiological salt solutions (PSS), cell culture media and to understand the role of each ingredient used in PSS preparation.
- 9. To study the instrumentation used for isolated tissue experiments (students organ bath assembly) and recent development in recording of the responses of isolated tissues.
- 10. To record the dose response curve of any two agonists on suitable isolated tissue preparation using computer simulation experiment.
- 11. To study the potentiating effect of physostigmine on DRC of acetyl choline through interactive computer simulation.
- 12. To study antagonizing effect of d-tubocurarine on the DRCs of acetylcholine through interactive computer simulation.
- 13. To determine of PD2 of given agonists using isolated tissue preparation using computer simulation experiment.
- 14. To study and determine various pharmacokinetic parameters (Cmax, Tmax, Ke, t½, Vd, Clt, AUC, AUMC) from given hypothetical data.
- 15. To estimate LD₅₀ using hypothetical data through computer-simulated experimentation (as per OECD 425 guideline) using software.
- 16. Software based quantification of micronucleus test and chromosomal aberration test
- 17. Software based prediction of teratogenicity.
Get complete notes for BP309P
Click any unit above to download its PDF notes — free, no login required
Recommended Textbooks & References
- Ghosh, M. N. Fundamentals of Experimental Pharmacology. Hilton & Company, Kolkata.
- Vogel, H. G. Drug Discovery and Evaluation: Pharmacological Assays. Springer.
- Hofmann, F. B. Handbook of Experimental Pharmacology (HEP Series). Springer Nature.
- Organisation for Economic Co-operation and Development. OECD Guidelines for the Testing of Chemicals.
- International Council for Harmonisation. ICH Guideline S7A: Safety Pharmacology Studies for Human Pharmaceuticals.
- International Council for Harmonisation. ICH Guideline S7B: Nonclinical Evaluation of the Potential for Delayed Ventricular Repolarization.
What's coming next on this page
- Previous year question papers (PYQ)
- Topic-wise short notes and revision summaries
- MCQs and self-assessment quizzes
- Suggested external resources and video tutorials
Other subjects in Semester 3
BP301TIntroduction to Machine Learning in Pharmaceutical SciencesBP302TEnvironmental SciencesBP303TEthics and Universal Human ValuesBP304TGeneral PharmacologyBP305THeterocyclic Compounds and StereochemistryBP306TPharmaceutical Dosage Forms IBP307TPharmaceutical EngineeringBP308TPharmaceutical MicrobiologyBP310PHeterocyclic Compounds and Stereochemistry (Practical)BP311PPharmaceutical Dosage Forms I (Practical)BP312P AECAEC Elective — Nutraceuticals / Food Analysis / Yoga & Life Sciences (Practical)