BP802TSemester 82 creditsTheory
Clinical Pharmacotherapeutics
Complete unit-wise syllabus for BP802T as per the PCI B.Pharm NEP 2020 curriculum (Semester 8 — AI Ethics + Clinical + Final Research).
URL:
https://pharmacode.vercel.app/syllabus/semester-8/bp802t-clinical-pharmacotherapeutics/Unit-wise Syllabus
5 Units1
Drug Therapy in Special Populations6 Hours- Paediatric pharmacotherapy: pharmacokinetic differences (absorption, distribution, metabolism, excretion); dosing methods (mg/kg, BSA, age-based rules — Young's, Clark's); off-label drug use; paediatric formulation challenges
- Geriatric pharmacotherapy: age-related PK/PD changes; polypharmacy assessment; Beers criteria; START/STOPP criteria; fall risk medications; dose adjustment in elderly
- Drug therapy in pregnancy and lactation: teratogen classification; risk-benefit assessment; drugs safe in pregnancy; breastfeeding safety (LactMed, Hale's Lactation Risk Categories)
2
Pharmacotherapy of Cardiovascular Diseases6 Hours- Heart failure: pathophysiology; ACE inhibitors/ARBs, beta-blockers, aldosterone antagonists, diuretics, sacubitril/valsartan (ARNI) — evidence-based pharmacotherapy; pharmacist monitoring parameters
- Acute Coronary Syndrome (ACS): antiplatelet therapy (aspirin, clopidogrel, ticagrelor), anticoagulants, fibrinolytics, GP IIb/IIIa inhibitors; STEMI vs. NSTEMI management
- Dyslipidaemia: statin therapy (intensity-based dosing), ezetimibe, PCSK9 inhibitors, fibrates; cardiovascular risk calculators; monitoring and target LDL levels
3
Pharmacotherapy of Endocrine and Metabolic Disorders6 Hours- Diabetes mellitus management: insulin regimens (basal-bolus, premixed); ADA/IDF glycaemic targets; algorithm-based selection of oral/injectable antidiabetics; hypoglycaemia management; sick-day rules
- Thyroid disorders: levothyroxine dosing and monitoring in hypothyroidism; antithyroid drug management of hyperthyroidism; thyroid crisis/myxoedema coma — emergency management
- Obesity pharmacotherapy: orlistat, GLP-1 agonists (semaglutide, liraglutide) in obesity; bariatric surgery and pharmacokinetic changes; metabolic syndrome management
4
Pharmacotherapy of Infectious Diseases6 Hours- Sepsis and septic shock: Surviving Sepsis Campaign guidelines; antibiotic choice and de-escalation; pharmacokinetic/pharmacodynamic (PK/PD) optimisation of antibiotics in ICU (AUC/MIC, T>MIC, Cmax/MIC targets)
- Tuberculosis: RNTCP/NTEP treatment regimens (DOTS-Plus); anti-TB drug monitoring; management of MDR-TB and XDR-TB; pharmacovigilance of anti-TB drugs
- HIV pharmacotherapy: WHO preferred first-line ART regimens; adherence strategies; opportunistic infection prophylaxis; drug-drug interactions with ART
5
Dosing in Renal and Hepatic Impairment6 Hours- Renal impairment: creatinine clearance calculation (Cockcroft-Gault); drug dose adjustment using GFR (Aronoff guidelines); drugs to avoid in renal failure; haemodialysis supplemental dosing
- Hepatic impairment: Child-Pugh and MELD scoring; impact on drug metabolism (CYP3A4 reduction, glucuronidation) and protein binding; dose reduction strategies; drugs contraindicated in liver disease
- Drug interactions in clinical practice: clinically significant PK and PD interactions; interaction severity classification; pharmacist interventions; use of drug interaction databases (Lexicomp, Micromedex, Medscape)
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What's coming next on this page
- Reference textbooks and recommended reading list
- Previous year question papers (PYQ)
- Topic-wise short notes and revision summaries
- Suggested external resources and video tutorials
Other subjects in Semester 8
BP801TEthical Considerations and Translational Applications of AI in PharmacyBP803TIndustrial Pharmacy and Facility DesignBP804TPharmaceutical ManagementBP805TSterile Dosage Forms and Novel Drug Delivery SystemBP806T AECAEC Elective (Pharma Packaging / Supply Chain / Industrial Safety / Traditional Healing / AR-VR Pharma 4.0 / Herbal Cosmetics)BP807P + BP808PPracticals — Pharmaceutical Marketing Skills + Sterile Dosage Forms + VAC ElectiveBP810RPResearch Project (Final Submission)